PC 707 – Advanced medicinal chemistry

Course lecturer :

Prof Rasha ElBayaa
prof Soad ElHawash
Hala fouad

Course assistant :

Course objectives :

To provide the student with the advanced fundamental aspects and current methodologies involved in drug discovery of lead compounds, drug development & drug production from different sources. It orients the students’ attention to the importance of pharmacokinetic and pharmacodynamic properties of drugs. It reinforces a deeper pharmaceutical understanding of the mechanism of drug action (MOA), drug receptors and their classification, drug-target interactions, the structure activity relationship (SAR) of the studied drugs, and the fate and metabolism of drugs

Course description :

Enzyme inhibitors as therapeutic agents.
– Protein pharmaceuticals & the use of biotechnology in their production.
– Gene therapy.
– Selective estrogen receptor modulators (SERM).
– Novel targets for the design of anticancer agents.
– Prodrugs (Drug latentiations).
– Radiopharmaceutical.
– Nitric oxide & its role in physiological & pathophysiological states.
– Drug metabolism of some of the commonly used drugs

Course assessment :

Assignments -oral -written exam- self study

Recommended text books :

1- Medicinal Chemistry, An introduction. by Gareth Thomas, 2007, John Wiley & Sons.
Foye’s Principles of Medicinal Chemistry, by Tomas L.Lemke& Others.2013. Lippincott Williams& Wilkins.

Recommended refrences :

1- Molecules and Medicine, 1st Edition by E. J. Corey, László Kürti, Barbara Czakó, 2008, John Wiley & Sons, Incorporated.
An Introduction to Medicinal Chemistry, 5th Edition by Graham L. Patrick, Oxford