PC 707 – Advanced medicinal chemistry

Prof Rasha ElBayaa
prof Soad ElHawash
Hala fouad

To provide the student with the advanced fundamental aspects and current methodologies involved in drug discovery of lead compounds, drug development & drug production from different sources. It orients the students’ attention to the importance of pharmacokinetic and pharmacodynamic properties of drugs. It reinforces a deeper pharmaceutical understanding of the mechanism of drug action (MOA), drug receptors and their classification, drug-target interactions, the structure activity relationship (SAR) of the studied drugs, and the fate and metabolism of drugs

Enzyme inhibitors as therapeutic agents.
– Protein pharmaceuticals & the use of biotechnology in their production.
– Gene therapy.
– Selective estrogen receptor modulators (SERM).
– Novel targets for the design of anticancer agents.
– Prodrugs (Drug latentiations).
– Radiopharmaceutical.
– Nitric oxide & its role in physiological & pathophysiological states.
– Drug metabolism of some of the commonly used drugs

Assignments -oral -written exam- self study

1- Medicinal Chemistry, An introduction. by Gareth Thomas, 2007, John Wiley & Sons.
Foye’s Principles of Medicinal Chemistry, by Tomas L.Lemke& Others.2013. Lippincott Williams& Wilkins.

1- Molecules and Medicine, 1st Edition by E. J. Corey, László Kürti, Barbara Czakó, 2008, John Wiley & Sons, Incorporated.
An Introduction to Medicinal Chemistry, 5th Edition by Graham L. Patrick, Oxford